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Diablo 4 | Anniversary Event Trailer
⏲ 1:54 👁 30K
Diablo II: Resurrected - Dupe method - patch 2.4 2.5
⏲ 1 minute 14 seconds 👁 28.5K
WHAT DIABLO 2 - VERSION 1.0 DID RIGHT!!! (And Wrong)
⏲ 12 minutes 9 seconds 👁 19.1K
The Wreck of the Edmund Fitzgerald
⏲ 5:20 👁 20K
HOW TO Run Multiple Diablo II Clients in 1.14D PATCH! [NEW]
⏲ 14 minutes 👁 12.6K
Most Powerful Weapons 1.09 Patch - Diablo 2
⏲ 3 minutes 50 seconds 👁 43.3K
Old Admirals
⏲ 3:54 👁 10K
Diablo 2 - How to install Plugy for 1.14d!!
⏲ 8 minutes 24 seconds 👁 32.8K
Diablo 2 patch update and more!
⏲ 9 minutes 35 seconds 👁 2.2K
How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
Diablo 2 was BETTER Pre-Expansion - Sweet Phil and GGM
⏲ 2 minutes 2 seconds 👁 1.5K
Coooley Reacts to Diablo 2's Newest Patch
⏲ 10 minutes 36 seconds 👁 19.4K
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_diablo-2-patch-update-and-more.jpg "craftchest")
_diablo-4-124-anniversary-event-trailer.webp "Diablo 4 is an action RPG developed by Blizzard Entertainment. In celebratory fashion for the anniversary of Diablo 4, players can access the March of the Goblins, Mother's Blessing, in-game cosmetics, and much more. Diablo 4's Anniversary Event is available now for PlayStation 4 (PS4), PlayStation 5 (PS5), Xbox One, Xbox Series X|S, and PC (BattleNet).")
_diablo-ii-resurrected-dupe-method-patch-2-4-2-5.webp "Jeremy Glitch")
_what-diablo-2-version-1-0-did-right-and-wrong.webp "MrLlamaSC")
_the-wreck-of-the-edmund-fitzgerald.webp "A cover song tribute to the crew of the Big Fitz and Mr. Lightfoot performed solo with acoustic guitar, voice, and foot piano playing orchestra strings.<br/><br/>Music and lyrics by Gordon Lightfoot<br/><br/>Robert S. - Ovation acoustic guitar, vocals, and Roland PK 5A Dynamic MIDI foot pedals triggering and horn patch on a Yamaha Motif rack mount sound module.")
_how-to-run-multiple-diablo-ii-clients-in-1-14d-patch-new.webp "OfficialAbyssGaming")
_most-powerful-weapons-1-09-patch-diablo-2.webp "Xtimus")
_old-admirals.webp "Solo cover performance on acoustic guitar, voice and foot piano playing a horn section.<br/><br/>Music and lyrics by Al Stewart<br/><br/>Robert S. - Ovation acoustic guitar, vocals, and Roland PK 5A Dynamic MIDI foot pedals triggering and horn patch on a Yamaha Motif rack mount sound module.")
_diablo-2-how-to-install-plugy-for-1-14d.webp "MrLlamaSC")
_diablo-2-patch-update-and-more.webp "craftchest")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_diablo-2-was-better-pre-expansion-sweet-phil-and-ggm.webp "Sweet Phil Clips")
_coooley-reacts-to-diablo-239s-newest-patch.webp "Coooley")
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